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Peptide Library / Immune / Longevity

Thymalin

Thymus polypeptide fraction

Thymalin Research Protocol

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

Thymalin is a thymic peptide bioregulator — a complex of polypeptides extracted from (or synthesised to mirror) the thymus gland. Developed in Russian gerontology, it is studied for restoring immune function, especially in aging, and for healthspan effects.

Reconstitution
Add 2.0 mL bacteriostatic water to a 10 mg vial → 5 mg/mL
Literature Range
5–10 mg daily (short course)
Measuring Reference
At 5 mg/mL: 10 mg = 2.0 mL = 200 units
Frequency
Daily during course
Route (studies)
SC/IM
Cycle
5–10 day courses

Scientific Data

Molecular Formula
—
Molecular Weight
—
Sequence
Thymus peptide complex
Sequence Length
20
CAS
Research compound
Peptide Family
Thymic bioregulator
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 10 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
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Concentration
5.00 mg/mL
Draw Volume
2.000 mL
Syringe Units
200.0 U
Doses / Vial
1

Units assume a U-100 insulin syringe (100 units = 1 mL). Dosed in short intensive courses (like other bioregulators), 1–2× per year.

Frequency: Daily (short course)

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 2-week protocol at approximately 10000 mcg per day.

Peptide (10 mg vials)
Estimate vials from total mass: 10000 mcg/day × 14 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model thymic immune restoration and healthspan.
Schedule
5–10 day courses, 1–2×/year.
Dose Range
5–10 mg/day.

Dosing Protocol

Standard
5–10 mg daily for a 5–10 day course
Frequency
Daily during the course
Cycle
Short courses repeated 1–2× per year
Cycle Length
5–10 days
Timing
Not time-critical
Route
Subcutaneous or intramuscular

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Most evidence originates from Russian gerontology research.
  • Commonly paired with epithalon in longevity protocols.

How This Works

Thymalin regulates the balance of T-lymphocyte populations, supporting maturation of T-cells and normalising immune indices that decline with age (immunosenescence). As a peptide bioregulator it is proposed to act on gene-expression patterns in immune and endocrine tissue. Long-term observational Russian studies associated periodic thymalin (often with epithalamin) with reduced morbidity and mortality in elderly cohorts.

Potential Benefits & Side Effects

Reported in research
  • Restoration of T-cell balance and immune indices
  • Studied for reversing age-related immune decline
  • Associated with reduced morbidity in elderly observational cohorts
  • Often combined with pineal peptides (epithalon) in protocols
Possible considerations
  • Injection-site reactions
  • Limited independent (non-Russian) data
  • Mild and infrequent side effects reported
  • Human evidence is largely observational

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Biogerontology
    Khavinson V.Kh. & Morozov V.G. Peptides of thymus and pineal gland prolong life.
    View Source