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Peptide Library / Growth Hormone / Longevity

Sermorelin

GHRH (1-29)

Sermorelin Research Protocol & Dosing Reference

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

Sermorelin is the 1–29 amino-acid fragment of growth-hormone-releasing hormone (GHRH) — the shortest sequence that retains full GHRH activity. It stimulates the pituitary to release growth hormone in a natural, pulsatile manner and preserves the body's own feedback control.

Reconstitution
Add 2.0 mL bacteriostatic water to a 5 mg vial → 2.5 mg/mL
Literature Range
100–300 mcg per administration
Measuring Reference
At 2.5 mg/mL: 200 mcg = 0.08 mL = 8 units
Frequency
1–2× daily
Route (studies)
Subcutaneous
Cycle
12–24 weeks

Scientific Data

Molecular Formula
—
Molecular Weight
3357.9 Da
Sequence
GRF(1-29)NH2
Sequence Length
5
CAS
Research compound
Peptide Family
GHRH analog
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 5 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
Full Precision Calculator →
Concentration
2.50 mg/mL
Draw Volume
0.080 mL
Syringe Units
8.0 U
Doses / Vial
25

Units assume a U-100 insulin syringe (100 units = 1 mL). Fasted pre-bed dosing aligns with the largest endogenous GH pulse.

Frequency: Nightly, fasted

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 16-week protocol at approximately 200 mcg per day.

Peptide (5 mg vials)
Estimate vials from total mass: 200 mcg/day × 112 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model physiological, pulsatile GH release via GHRH receptors.
Schedule
Daily, 12–24 weeks.
Dose Range
100–300 mcg/day.

Dosing Protocol

Start
100–200 mcg once daily before sleep
Target Range
200–300 mcg/day
Frequency
Nightly; some add a fasted AM dose
Cycle Length
12–24 weeks
Timing
Fasted, pre-bed aligns with the largest natural GH pulse
Route
Subcutaneous

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Preserves pituitary feedback — a key safety distinction from exogenous GH.
  • Fasted timing is important for an effective GH pulse.
  • Monitor IGF-1 in longer protocols.

How This Works

Sermorelin binds GHRH receptors on pituitary somatotrophs, raising cAMP and triggering synthesis and pulsatile release of growth hormone. Because the pituitary remains subject to somatostatin feedback, GH is released physiologically rather than continuously, reducing the risk of excessive levels. The downstream GH pulse raises IGF-1 and supports body composition, recovery and sleep architecture.

Potential Benefits & Side Effects

Reported in research
  • Stimulated endogenous, pulsatile GH release
  • Increased IGF-1 within physiological ranges
  • Improved sleep quality and recovery markers
  • Preserved natural feedback regulation vs exogenous GH
  • Supports lean mass and reduced fat mass in studies
Possible considerations
  • Injection-site redness, swelling or itching
  • Flushing or head-rush post-dose
  • Headache or dizziness
  • Rarely altered taste

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Journal of Clinical Endocrinology & Metabolism
    Walker R.F. Sermorelin: a better approach to GH replacement therapy?
    View Source