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Peptide Library / Cognition / Longevity

Pinealon

Tripeptide bioregulator (Glu-Asp-Arg)

Pinealon Research Protocol

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

Pinealon is a short synthetic tripeptide bioregulator (Glu-Asp-Arg) in the Khavinson peptide family. It is studied for neuroprotection, cognitive support and antioxidant gene regulation, with the ability to penetrate cells and reach the nucleus.

Reconstitution
Add 2.0 mL bacteriostatic water to a 10 mg vial → 5 mg/mL
Literature Range
5–10 mg daily (short course)
Measuring Reference
At 5 mg/mL: 10 mg = 2.0 mL = 200 units
Frequency
Daily during course
Route (studies)
SC/IM
Cycle
10–20 days

Scientific Data

Molecular Formula
—
Molecular Weight
383.4 Da
Sequence
Glu-Asp-Arg
Sequence Length
9
CAS
Research compound
Peptide Family
Bioregulator
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 10 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
Full Precision Calculator →
Concentration
5.00 mg/mL
Draw Volume
2.000 mL
Syringe Units
200.0 U
Doses / Vial
1

Units assume a U-100 insulin syringe (100 units = 1 mL). A Khavinson bioregulator dosed in short courses, like epithalon and thymalin.

Frequency: Daily (short course)

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 2-week protocol at approximately 10000 mcg per day.

Peptide (10 mg vials)
Estimate vials from total mass: 10000 mcg/day × 14 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model neuroprotective peptide-bioregulator effects.
Schedule
10–20 day courses.
Dose Range
5–10 mg/day.

Dosing Protocol

Standard
5–10 mg daily for a short course
Frequency
Daily during the course
Cycle
10–20 day courses, repeated periodically
Cycle Length
10–20 days
Timing
Not time-critical
Route
Subcutaneous or intramuscular

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Dosed in short courses like other Khavinson bioregulators.
  • Human evidence is largely from Russian research.

How This Works

Pinealon is small enough to enter cells and even the nucleus, where it is proposed to act as a gene-expression bioregulator — modulating transcription of genes involved in antioxidant defence, neuronal survival and apoptosis. In animal models it protected neurons against oxidative and hypoxic stress, reduced markers of oxidative damage and supported learning and memory, consistent with the bioregulator concept of short peptides 'tuning' tissue-specific gene programs.

Potential Benefits & Side Effects

Reported in research
  • Neuroprotection against oxidative/hypoxic stress
  • Antioxidant gene regulation
  • Supported learning and memory in animal models
  • Cell- and nucleus-penetrating bioregulator
Possible considerations
  • Injection-site reactions
  • Limited independent human data
  • Mild and infrequent effects reported
  • Evidence largely from Russian research

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Bulletin of Experimental Biology and Medicine
    Khavinson V.Kh. et al. Neuroprotective effects of peptide Pinealon.
    View Source