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Peptide Library / Growth Hormone / Recovery

MGF

Mechano Growth Factor (IGF-1Ec)

MGF (Mechano Growth Factor) Research Protocol

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

MGF is a splice variant of IGF-1 (IGF-1Ec) produced locally in muscle in response to mechanical overload or damage. It is studied for activating satellite (muscle stem) cells and initiating local repair and hypertrophy.

Reconstitution
Add 1.0 mL bacteriostatic water to a 2 mg vial → 2 mg/mL
Literature Range
100–200 mcg post-training
Measuring Reference
At 2 mg/mL: 200 mcg = 0.1 mL = 10 units
Frequency
Training days
Route (studies)
Local SC/IM
Half-life
Minutes (native)

Scientific Data

Molecular Formula
—
Molecular Weight
2867 Da
Sequence
IGF-1 Ec C-terminal peptide
Sequence Length
21
CAS
Research compound
Peptide Family
IGF splice variant
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 2 mg vial · 1 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
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Concentration
2.00 mg/mL
Draw Volume
0.100 mL
Syringe Units
10.0 U
Doses / Vial
10

Units assume a U-100 insulin syringe (100 units = 1 mL). Native MGF clears in minutes; dose locally and immediately post-training.

Frequency: Training days, post-workout

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 1.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 6-week protocol at approximately 200 mcg per day.

Peptide (2 mg vials)
Estimate vials from total mass: 200 mcg/day × 42 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model local satellite-cell activation and muscle repair.
Schedule
Training days, 4–6 weeks.
Dose Range
100–200 mcg per site.

Dosing Protocol

Standard
200 mcg post-training near worked muscle
Frequency
On training days
Target
100–200 mcg per site
Cycle Length
4–6 weeks
Timing
Immediately post-workout
Route
Subcutaneous/IM near the muscle

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Native MGF's minutes-long half-life means timing and local placement matter.
  • Human evidence is limited; most data is cellular/animal.

How This Works

Mechanical loading causes muscle to express the IGF-1Ec splice variant, whose unique C-terminal peptide (MGF) activates muscle satellite cells, promoting their proliferation and fusion into damaged fibres. This 'kick-starts' local repair ahead of the systemic IGF-1 response. Native MGF has a very short half-life (minutes), so it is dosed locally and close to training in research protocols.

Potential Benefits & Side Effects

Reported in research
  • Satellite-cell activation and proliferation
  • Initiation of local muscle repair after damage
  • Supports hypertrophy when paired with training
  • Studied for neuroprotection as well
Possible considerations
  • Very short half-life limits systemic effect
  • Injection-site reactions
  • Limited human data
  • Often used post-training for local effect

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Journal of Physiology
    Goldspink G. Mechano growth factor and muscle repair.
    View Source