CG Labz
Peptide Library / Cognition / Neuro

Selank

Tuftsin analog

Selank Research Protocol

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, developed in Russia as an anxiolytic. It reduces anxiety without the sedation, tolerance or dependence of benzodiazepines, and is usually administered intranasally.

Reconstitution
Reconstitute to intranasal solution (or SC with bac water)
Literature Range
250–750 mcg per dose
Measuring Reference
Metered intranasal spray
Frequency
1–3× daily
Route (studies)
Intranasal
Cycle
2–4 weeks

Scientific Data

Molecular Formula
—
Molecular Weight
751.9 Da
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Sequence Length
21
CAS
Research compound
Peptide Family
Anxiolytic heptapeptide
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 10 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
Full Precision Calculator →
Concentration
5.00 mg/mL
Draw Volume
0.100 mL
Syringe Units
10.0 U
Doses / Vial
20

Units assume a U-100 insulin syringe (100 units = 1 mL). A non-sedating anxiolytic; pairs well with Semax (focus) in a cognition stack.

Frequency: 1–3× daily (intranasal)

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 4-week protocol at approximately 500 mcg per day.

Peptide (10 mg vials)
Estimate vials from total mass: 500 mcg/day × 28 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model GABAergic anxiolysis and stress resilience.
Schedule
Daily, 2–4 week cycles.
Dose Range
250–750 mcg/dose.

Dosing Protocol

Standard
250–750 mcg per dose
Frequency
1–3× daily
Target
400–500 mcg typical
Cycle Length
2–4 weeks on, 1–2 off
Timing
Can be dosed later for stress/sleep
Route
Intranasal (or SC)

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Non-sedating and non-dependence-forming in studies.
  • Often paired with Semax for a focus + calm stack.

How This Works

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) modulates GABA-A receptor expression and increases BDNF, producing anxiolytic effects comparable to benzodiazepines in animal models but without sedation or withdrawal. It also normalises the balance of pro- and anti-inflammatory cytokines (notably IL-6) and inhibits enkephalinase, extending endogenous regulatory peptides. It has mild nootropic and immune-balancing properties alongside its calming effect.

Potential Benefits & Side Effects

Reported in research
  • Anxiolytic effect without sedation or dependence
  • GABAergic modulation and increased BDNF
  • Immune/cytokine balancing (e.g. IL-6 normalisation)
  • Mild nootropic and stress-resilience effects
  • Rapid intranasal onset
Possible considerations
  • Nasal irritation (intranasal route)
  • Fatigue or 'flatness' at high doses
  • Mild and infrequent side effects
  • Limited Western clinical data

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Tilt the head slightly forward and insert the metered sprayer into one nostril.
  2. 2Occlude the opposite nostril and sniff gently as you actuate the spray.
  3. 3Alternate nostrils between doses; do not blow the nose for ~10 minutes.
  4. 4Refrigerate the sprayer between uses and label with the fill date.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Neuroscience and Behavioral Physiology
    Kozlovskaya M.M. et al. Selank and tuftsin peptides in stress regulation.
    View Source