CG Labz
Peptide Library / Hormone / Fertility

HMG

Human Menopausal Gonadotropin

HMG (Human Menopausal Gonadotropin) Research Protocol

Complete Research Guide 4 min read1 peer-reviewed references

Quickstart Overview

HMG (menotropin) is a purified gonadotropin preparation with combined FSH and LH activity. It is used in fertility research to stimulate both follicular development (FSH) and sex-hormone production (LH), and in men to support full spermatogenesis.

Reconstitution
Reconstitute per vial IU with bacteriostatic water
Literature Range
75–150 IU per administration
Measuring Reference
Dose by IU per protocol
Frequency
Several×/week
Route (studies)
SC/IM
Activity
FSH + LH

Scientific Data

Molecular Formula
—
Molecular Weight
—
Sequence
FSH + LH activity
Sequence Length
13
CAS
Research compound
Peptide Family
Gonadotropin
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 0 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
Full Precision Calculator →
Concentration
5.00 mg/mL
Draw Volume
0.015 mL
Syringe Units
1.5 U
Doses / Vial
133

Units assume a U-100 insulin syringe (100 units = 1 mL). Provides both FSH and LH activity; dosed in IU under monitored protocols.

Frequency: Several×/week

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 8-week protocol at approximately 75 mcg per day.

Peptide (0 mg vials)
Estimate vials from total mass: 75 mcg/day × 56 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model combined FSH/LH gonadotropin stimulation.
Schedule
Several×/week, protocol-based.
Dose Range
75–150 IU per dose.

Dosing Protocol

Standard
75–150 IU per administration
Frequency
Several times weekly per protocol
Target
Per fertility/spermatogenesis protocol
Cycle Length
Protocol-dependent
Timing
Per monitored protocol
Route
Subcutaneous or intramuscular

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Dosed in IU; fertility use requires monitoring (ovarian hyperstimulation risk).
  • Chosen over HCG when FSH activity is required.

How This Works

HMG supplies both FSH and LH activity. FSH stimulates follicular growth in women and Sertoli-cell-supported spermatogenesis in men, while the LH component drives Leydig-cell testosterone (or ovarian theca-cell steroidogenesis). Because it provides both signals, HMG is used where FSH is needed in addition to LH-like stimulation — for example restoring full fertility where HCG alone (LH activity only) is insufficient.

Potential Benefits & Side Effects

Reported in research
  • Combined FSH + LH gonadotropin activity
  • Stimulation of follicular development (fertility)
  • Support for complete spermatogenesis in men
  • Used where FSH is required alongside LH stimulation
Possible considerations
  • Injection-site reactions
  • Ovarian hyperstimulation risk (fertility context)
  • Oestrogen/hormone fluctuations
  • Requires monitoring in fertility protocols

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Fertility and Sterility
    Menotropin (HMG) in gonadotropin therapy.
    View Source