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Peptide Library / Growth Hormone / Performance

Hexarelin

Growth Hormone Releasing Peptide

Hexarelin Research Protocol

Complete Research Guide 4 min read2 peer-reviewed references

Quickstart Overview

Hexarelin is the most potent peptide of the GHRP family and the most studied for direct cardiac effects. Beyond strong GH release it binds CD36 receptors in cardiovascular tissue, giving it a research profile distinct from other secretagogues.

Reconstitution
Add 2.0 mL bacteriostatic water to a 5 mg vial → 2.5 mg/mL
Literature Range
100–200 mcg per administration
Measuring Reference
At 2.5 mg/mL: 100 mcg = 0.04 mL = 4 units
Frequency
1–2× daily
Route (studies)
Subcutaneous
Cycle
4–8 weeks

Scientific Data

Molecular Formula
—
Molecular Weight
887 Da
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Sequence Length
28
CAS
Research compound
Peptide Family
GHRP
Half-life
Refer to published literature
Solubility
Bacteriostatic water, sterile saline
Storage
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 2–4 weeks.
Appearance
White lyophilized powder
Standard: 5 mg vial · 2 mL diluent

Dosing & Reconstitution Guide

Interactive Reconstitution
Adjust vial size, diluent and target dose. Results update live.
Full Precision Calculator →
Concentration
2.50 mg/mL
Draw Volume
0.040 mL
Syringe Units
4.0 U
Doses / Vial
50

Units assume a U-100 insulin syringe (100 units = 1 mL). Most potent GHRP; prone to desensitisation, so cycle rather than run continuously.

Frequency: 1–2× daily, fasted

Reconstitution Steps

  1. 1Allow the lyophilized vial and bacteriostatic water to reach room temperature (~15 min).
  2. 2Swab both vial stoppers with a fresh 70% isopropyl alcohol pad and let them dry.
  3. 3Draw 2.0 mL of bacteriostatic water into a mixing syringe.
  4. 4Insert at an angle and let the water run slowly down the glass wall — never directly onto the powder.
  5. 5Gently swirl (do not shake) until the solution is completely clear.
  6. 6Label with date and concentration (mg/mL) and refrigerate at 2–8 °C immediately.

Supplies Needed

Planning example for a 8-week protocol at approximately 200 mcg per day.

Peptide (5 mg vials)
Estimate vials from total mass: 200 mcg/day × 56 days.
Bacteriostatic Water
One 10–30 mL vial typically covers a full cycle.
Insulin Syringes (U-100)
One per administration (29–31 G, 0.3–0.5 mL).
Alcohol Swabs
Two per administration (vial + site).
Sharps Container
Required for safe disposal.

Protocol Overview

Goal
Model potent GH release plus CD36 cardioprotection.
Schedule
Daily, 4–8 week cycles.
Dose Range
100–200 mcg per dose.

Dosing Protocol

Start
100 mcg 1–2× daily
Target
100–200 mcg per dose
Frequency
1–2× daily; avoid continuous high dosing
Cycle Length
4–8 weeks, then break
Timing
Fasted
Route
Subcutaneous

Storage Instructions

Lyophilized
−20 °C long term (18–24 months); stable at room temperature for short transit.
Reconstituted
2–8 °C refrigerated; use within 4 weeks.
Light
Protect from direct light; keep in the original carton.
Freeze/Thaw
Avoid repeat freeze–thaw cycles after reconstitution.

Important Notes

  • Desensitisation is the key limiter — cycle hexarelin rather than dose it continuously.
  • Its CD36-mediated cardiac activity sets it apart from other GHRPs.

How This Works

Hexarelin activates the GHS-R1a ghrelin receptor for a powerful GH pulse and, uniquely, binds CD36 receptors in the heart and vasculature where it shows cardioprotective activity independent of GH. It is the most potent GHRP but also the most prone to receptor desensitisation, so it is typically cycled and not dosed continuously at high levels.

Potential Benefits & Side Effects

Reported in research
  • Most potent GH release of the GHRP family
  • Direct cardioprotective effects via CD36 (GH-independent)
  • Increased IGF-1 and recovery markers
  • Studied in cardiac ischemia models
Possible considerations
  • Receptor desensitisation with continuous high dosing
  • Cortisol/prolactin elevation at higher doses
  • Water retention
  • Head-rush/flushing
  • Appetite increase

Lifestyle Factors

  • Adequate hydration and 7–9 h of sleep are standard controls in most research protocols.
  • Consistent dose timing improves the reliability of any self-tracked endpoints.
  • Maintain a clean, sterile workflow for every draw to avoid contamination.

Injection Technique

  1. 1Wash hands, then prep the vial top and the target site with separate alcohol swabs.
  2. 2Pinch a subcutaneous skin fold (abdomen, ~2 inches from the navel) and insert at 45–90°.
  3. 3Depress the plunger slowly over 3–5 seconds, hold 5 seconds, then withdraw.
  4. 4Rotate sites each administration and dispose of the syringe in a sharps container.

Frequently Asked Questions

Third-party HPLC testing

CG Labz Verified Batches

No published batches yet.

Research Disclaimer

All compounds are supplied strictly for laboratory research. Dosing figures below summarize ranges reported in published preclinical and clinical literature for reference purposes only. CG Labz does not provide medical advice or individualized dosing recommendations.

Peer-reviewed literature

References

  1. [1] Journal of Clinical Endocrinology & Metabolism
    Ghigo E. et al. Hexarelin, a potent GH-releasing peptide.
    View Source
  2. [2] Cardiovascular Research
    Broglio F. et al. Hexarelin and the cardiovascular system (CD36).
    View Source